evaluation of the effects of caffeic acid phenethyl ester on prostaglandin e2 and two key cytokines involved in bleomycin-induced pulmonary fibrosis

Authors

amir larki-harchegani department of pharmacology and toxicology, school of pharmacy and physiology research center, jundishapur university of medical sciences, ahvaz, iran

ali asghar hemmati department of pharmacology and toxicology, school of pharmacy and physiology research center, jundishapur university of medical sciences, ahvaz, iran

ardeshir arzi department of pharmacology and toxicology, school of pharmacy and physiology research center, jundishapur university of medical sciences, ahvaz, iran

mehri ghafurian-boroojerdnia department of immunology, school of medicine, jundishapur university of medical sciences, ahvaz, iran

abstract

objective(s): pulmonary fibrosis (pf) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. it is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of pf in animal models and possibly in humans. caffeic acid phenethyl ester (cape), an active component of propolis, has numerous biological effects. in the present study, the main objective was to investigate the effects of cape on some key mediators including tgf-β1, tnf-α and prostaglandin e2 (pge2 ) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (ipf).   materials and methods: in this study, forty male sprague–dawley rats were divided into 5 groups (n=8). (1) “bleomycin (blm)-treated (model) group”: blm (5 mg/kg, single intratracheal dose), (2) “saline-treated group”: the rats were given only saline, (3) “treatment-1 group”: blm + cape (5 μmol/kg/day, 28 days, ip), (4) “treatment-2 group”: blm + cape (10 μmol/kg/day, 28 days, ip) and (5) “vehicle + cape group”: cape (10 μmol/kg/day, 28 days, ip). results: blm could significantly increase the levels of tnf-α and tgf-β1 and decrease the pge2 concentration compared to the saline control group. cape could considerably improve these values almost close to normal levels. conclusion: briefly, cape can be suggested as a novel, attractive and effective agent for prevention and treatment of pulmonary fibrosis.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis

  Objective(s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an...

full text

Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis

OBJECTIVE(S) Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active comp...

full text

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Amiodarone-Induced Pulmonary Fibrosis in Rat

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...

full text

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Amiodarone-Induced Pulmonary Fibrosis in Rat

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable dieases. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In th...

full text

protective effect of caffeic acid phenethyl ester (cape) on amiodarone-induced pulmonary fibrosis in rat

treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (pf) which is a commonly progressive and untreatable dieases. caffeic acid phenethyl ester (cape) is a phenolic antioxidant and an active anti-inflammatory, anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). in th...

full text

regulatory effect of caffeic acid phenethyl ester on type i collagen and interferon-gamma in bleomycin-induced pulmonary fibrosis in rat

idiopathic pulmonary fibrosis (ipf) is a chronic lung disease of unknown etiology. recent investigations have demonstrated that the impaired immune response is a common characteristic feature of ipf. unfortunately, no definitive and effective drug treatment is available that could improve or at least inhibit the progressive course of this fatal disease. that is why one of the main priorities of...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of basic medical sciences

جلد ۱۶، شماره ۷، صفحات ۸۵۰-۸۵۷

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023